CD4+T-cell subsets in intestinal inflammation

CD4+ T-cell subsets in intestinal inflammation

Intestinal CD4(+) T cells are essential mediators of immune homeostasis and inflammation. Multiple subsets of CD4(+) T cells have been described in the intestine, which represents an important site for the generation and regulation of cells involved in immune responses both within and outside of the gastrointestinal tract. Recent advances have furthered our understanding of the biology of suc...

leucocyte-endothelial cell adhesion in intestinal inflammation

Background-An important action of interleukin 8 (IL8) is stimulation ofgranulocytes. The object of this study was to assess the contribution ofIL8 to the leucocyte-endothelial celi interactions associated with intestinal inflammation in the rat. Methods-Two indomethacin injections (48 and 24 hours prior to the experiments) induced a longlasting ileitis in rats. The number of adherent and emigra...

Dendritic Cell Subsets in Asthma: Impaired Tolerance or Exaggerated Inflammation?

Asthma is a prevalent chronic heterogeneous inflammatory disease of the airways, leading to reversible airway obstruction, in which various inflammatory responses can be observed. Mild to moderate asthma patients often present with a Th2-mediated eosinophilic inflammation whereas in severe asthma patients, a Th17-associated neutrophilic or combined Th2 and Th17-mediated eosinophilic/neutrophili...

Intestinal secretory cell ER stress and inflammation.

Data from animal models and human inflammatory bowel diseases have implicated the ER (endoplasmic reticulum) stress pathway in intestinal inflammation. We have characterized the development of inflammation in Winnie mice in which ER stress arises due to a single missense mutation in the MUC2 mucin produced by intestinal goblet cells. This model has allowed us to explore the genesis of inflammat...

Dendritic Cell and Macrophage Subsets That Functional Specializations of Intestinal